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Transcription profiling of human biopsies from subcutaneous adipose tissue from unrelated individuals reveals galanin preproprotein is associated with elevated plasma triglycerides

ABSTRACT: Assessment of mRNA expression levels in fat biopsies from subcutaneous adipose tissue from unrelated individuals. Experiment Overall Design: Subcutaneous adipose tissue from 49 unrelated individuals.

ORGANISM(S): Homo sapiens

SUBMITTER: Christopher Plaisier 

PROVIDER: E-GEOD-13506 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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<h4>Objective</h4>There is increasing physiological evidence in rodents connecting the neuropeptide galanin to triglyceride (TG) levels. We hypothesized that variation in the galanin preproprotein (GAL) gene may contribute to hypertriglyceridemia (HTG) in humans.<h4>Methods and results</h4>We investigated GAL as a TG candidate gene by genotyping 4 tagSNPs in Dutch, Finnish, and Mexican familial combined hyperlipidemia (FCHL) families as well as in white combined hyperlipidemia cases/controls (n=  ...[more]

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