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Transcription profiling of human biopsies of Nasopharyngeal carcinoma (NPC) and non-malignant controls

ABSTRACT: Nasopharyngeal carcinoma (NPC) is a common cancer in southern China and South East Asia where more than 50,000 new cases are diagnosed each year. We used microarrays to identify down or upregulated genes in NPC compared with non-malignant controls. Experiment Overall Design: Snap frozen nasopharyngeal biopsies from 25 patients with histologically confirmed undifferentiated NPC were included in the microarray analysis. Controls were obtained from 3 patients with no evidence of malignancy.

ORGANISM(S): Homo sapiens

SUBMITTER: Wenbin Wei

PROVIDER: E-GEOD-13597 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The ATM tumour suppressor gene is down-regulated in EBV-associated nasopharyngeal carcinoma.

Bose Shikha S Yap Lee-Fah LF Fung Matthew M Starzcynski Jane J Saleh Amyza A Morgan Susan S Dawson Christopher C Chukwuma Marilyn B MB Maina Esther E Buettner Maike M Wei Wenbin W Arrand John J Lim Paul V H PV Young Lawrence S LS Teo Soo Hwang SH Stankovic Tatjana T Woodman Ciaran B J CB Murray Paul G PG

The Journal of pathology 20090201 3

A micro-array analysis using biopsies from patients with EBV-positive undifferentiated nasopharyngeal carcinoma (NPC) and from cancer-free controls revealed down-regulation of tumour suppressor genes (TSG) not previously associated with this disease; one such gene was the ataxia telangiectasia mutated (ATM) gene. Q-PCR confirmed down-regulation of ATM mRNA and ATM protein expression in tumour cells was weak or absent in almost all cases. In NPC cell lines, however, ATM was down-regulated only in ...[more]

PMID: 19142888

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