Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Wenbin Wei
PROVIDER: E-GEOD-13597 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
The Journal of pathology 20090201 3
A micro-array analysis using biopsies from patients with EBV-positive undifferentiated nasopharyngeal carcinoma (NPC) and from cancer-free controls revealed down-regulation of tumour suppressor genes (TSG) not previously associated with this disease; one such gene was the ataxia telangiectasia mutated (ATM) gene. Q-PCR confirmed down-regulation of ATM mRNA and ATM protein expression in tumour cells was weak or absent in almost all cases. In NPC cell lines, however, ATM was down-regulated only in ...[more]