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Transcription profiling of HeLa cells to investigate the effect of miRNA biogenesis factors on mRNA levels

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE13638: Ago2 or Dicer knockdown effects on mRNA levels in HeLa GSE13639: Drosha or DGCR8 knockdown effects on mRNA levels in HeLa Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Jinju Han

PROVIDER: E-GEOD-13640 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Posttranscriptional crossregulation between Drosha and DGCR8.

Han Jinju J Pedersen Jakob S JS Kwon S Chul SC Belair Cassandra D CD Kim Young-Kook YK Yeom Kyu-Hyeon KH Yang Woo-Young WY Haussler David D Blelloch Robert R Kim V Narry VN

Cell 20090101 1

The Drosha-DGCR8 complex, also known as Microprocessor, is essential for microRNA (miRNA) maturation. Drosha functions as the catalytic subunit, while DGCR8 (also known as Pasha) recognizes the RNA substrate. Although the action mechanism of this complex has been intensively studied, it remains unclear how Drosha and DGCR8 are regulated and if these proteins have any additional role(s) apart from miRNA processing. Here, we report that Drosha and DGCR8 regulate each other posttranscriptionally. T ...[more]

PMID: 19135890

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Ago2 or Dicer knockdown effects on mRNA levels in HeLa

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