Total-body irradiation dose response
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Marcy Grace
PROVIDER: E-GEOD-1366 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Human in vivo radiation-induced biomarkers: gene expression changes in radiotherapy patients.
Amundson Sally A SA Grace Marcy B MB McLeland Christopher B CB Epperly Michael W MW Yeager Andrew A Zhan Qimin Q Greenberger Joel S JS Fornace Albert J AJ
Cancer research 20040901 18
After initially identifying potential biomarkers of radiation exposure through microarray studies of ex vivo irradiated human peripheral white blood cells, we have now measured the in vivo responses of several of these biomarker genes in patients undergoing total body irradiation. Microarray analysis has identified additional in vivo radiation-responsive genes, although the general in vivo patterns of stress-gene induction appear similar to those obtained from ex vivo white blood cell experiment ...[more]
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