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Comparative genomic hybridization of human breast cancer cell lines (45) on Affymetrix 100K SNP arrays

ABSTRACT: Breast cancer cell lines grown in full serum under standard conditions were profiled on Affymetrix GeneChip Mapping 100K Set Arrays Experiment Overall Design: Profiling of cell lines grown under standard conditions

ORGANISM(S): Homo sapiens

SUBMITTER: Peter Haverty

PROVIDER: E-GEOD-13696 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genetic alterations and oncogenic pathways associated with breast cancer subtypes.

Hu Xiaolan X Stern Howard M HM Ge Lin L O'Brien Carol C Haydu Lauren L Honchell Cynthia D CD Haverty Peter M PM Peters Brock A BA Wu Thomas D TD Amler Lukas C LC Chant John J Stokoe David D Lackner Mark R MR Cavet Guy G

Molecular cancer research : MCR 20090401 4

Breast cancers can be divided into subtypes with important implications for prognosis and treatment. We set out to characterize the genetic alterations observed in different breast cancer subtypes and to identify specific candidate genes and pathways associated with subtype biology. mRNA expression levels of estrogen receptor, progesterone receptor, and HER2 were shown to predict marker status determined by immunohistochemistry and to be effective at assigning samples to subtypes. HER2(+) cancer ...[more]

PMID: 19372580

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Copy number profiling of 45 human breast cancer cell lines on Affymetrix 100K SNP arrays

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