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RNAi of Drosophila dTip60 in SL2 cells to investigate regulation of gene expression by the histone acetyltransferase dTip60

ABSTRACT: We used microarrays to detail the global gene expression changes following RNAi knock-down of dTip60 in Drosophila SL2 cells Experiment Overall Design: We compared SL2 cells treated with dTip60-RNAi with SL2 cells mock-treated with eGFP-RNAi to determine global gene expression changes by microarray analysis

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Ludger Klein-Hitpass 

PROVIDER: E-GEOD-13878 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Widespread regulation of gene expression in the Drosophila genome by the histone acetyltransferase dTip60.

Schirling Corinna C   Heseding Christiane C   Heise Franziska F   Kesper Dörthe D   Klebes Ansgar A   Klein-Hitpass Ludger L   Vortkamp Andrea A   Hoffmann Daniel D   Saumweber Harald H   Ehrenhofer-Murray Ann E AE  

Chromosoma 20091201 1

The MYST histone acetyltransferase (HAT) dTip60 is part of a multimeric protein complex that unites both HAT and chromatin remodeling activities. Here, we sought to gain insight into the biological functions of dTip60. Strong ubiquitous dTip60 knock-down in flies was lethal, whereas knock-down in the wing imaginal disk led to developmental defects in the wing. dTip60 localized to the nucleus in early embryos and was present in a large number of interbands on polytene chromosomes. Genome-wide exp  ...[more]

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