A Burst of Segmental Duplications in the African Great Ape Ancestor
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ABSTRACT:
ORGANISM(S): Macaca mulatta
SUBMITTER: Tomas Marques-Bonet
PROVIDER: E-GEOD-13934 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
A burst of segmental duplications in the genome of the African great ape ancestor.
Marques-Bonet Tomas T Kidd Jeffrey M JM Ventura Mario M Graves Tina A TA Cheng Ze Z Hillier LaDeana W LW Jiang Zhaoshi Z Baker Carl C Malfavon-Borja Ray R Fulton Lucinda A LA Alkan Can C Aksay Gozde G Girirajan Santhosh S Siswara Priscillia P Chen Lin L Cardone Maria Francesca MF Navarro Arcadi A Mardis Elaine R ER Wilson Richard K RK Eichler Evan E EE
Nature 20090201 7231
It is generally accepted that the extent of phenotypic change between human and great apes is dissonant with the rate of molecular change. Between these two groups, proteins are virtually identical, cytogenetically there are few rearrangements that distinguish ape-human chromosomes, and rates of single-base-pair change and retrotransposon activity have slowed particularly within hominid lineages when compared to rodents or monkeys. Studies of gene family evolution indicate that gene loss and gai ...[more]
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