Unknown,Transcriptomics,Genomics,Proteomics

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Paired non-cancerous and cancerous miRNA expression of esophageal adenocarcinoma and squamous cell carcinoma patients

ABSTRACT: Identifying biomarkers predictive for early esophageal cancer detection is critical considering the dismal survival rates. We investigated the involvement of microRNAs (miRNAs), their utility as biomarkers, and their association with survival in esophageal cancer, including Barrett’s associated and sporadic adenocarcinoma (ADC), and squamous cell carcinoma (SCC). MiRNA expression was measured in cancerous and adjacent non-cancerous tissue pairs collected from 76 US and Japanese patients enrolled in 3 distinct cohorts. In ADC patients, miR-21, miR-194, miR-293, and miR-223 expression was elevated, while miR-375 and miR-203 expression was reduced in cancerous tissue compared to non-cancerous tissue. Increased levels of miR-192 and miR-194 were observed in Barrett’s associated compared to sporadic ADC cancerous tissue. In SCC patients, miR-21, miR-181b, miR-155, and miR-146b expression was elevated while miR-375 and miR-203 levels were reduced in cancerous tissue compared to non-cancerous tissue. Significantly, elevated mir-21 expression in non-cancerous tissue was strongly associated with worse prognosis, independent of nodal status and age. Sample classification using miRNA expression yielded accuracies as high as 86% for diagnosis and 78% for Barrett’s esophagus status. Our results highlight that miRNAs are deregulated in esophageal carcinogenesis and Barrett’s esophagus, and that their expression is associated with survival in cancer patients. Sample classification using miRNA expression demonstrates their potential utility as biomarkers for esophageal carcinoma diagnosis. MiRNA microarray expression was measured using miRNA microarray chips version 3 (Ohio State University) in 44 SCC cases and 32 ADC cases, of which 18 were also diagnosed with Barrett’s esophagus.

ORGANISM(S): Homo sapiens

SUBMITTER: Ewy Mathe 

PROVIDER: E-GEOD-13937 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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MicroRNA expression in squamous cell carcinoma and adenocarcinoma of the esophagus: associations with survival.

Mathé Ewy A EA   Nguyen Giang Huong GH   Bowman Elise D ED   Zhao Yiqiang Y   Budhu Anuradha A   Schetter Aaron J AJ   Braun Rosemary R   Reimers Mark M   Kumamoto Kensuke K   Hughes Duncan D   Altorki Nasser K NK   Casson Alan G AG   Liu Chang-Gong CG   Wang Xin Wei XW   Yanaihara Nozomu N   Hagiwara Nobutoshi N   Dannenberg Andrew J AJ   Miyashita Masao M   Croce Carlo M CM   Harris Curtis C CC  

Clinical cancer research : an official journal of the American Association for Cancer Research 20090929 19

<h4>Purpose</h4>The dismal outcome of esophageal cancer patients highlights the need for novel prognostic biomarkers, such as microRNAs (miRNA). Although recent studies have established the role of miRNAs in esophageal carcinoma, a comprehensive multicenter study investigating different histologic types, including squamous cell carcinoma (SCC) and adenocarcinoma with or without Barrett's, is still lacking.<h4>Experimental design</h4>miRNA expression was measured in cancerous and adjacent noncanc  ...[more]

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