Browse
Submit Data
Databases
API
Help

Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

45 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Comparison of gamma delta intraepithelial lymphocytes from DSS-treated and untreated colon

ABSTRACT: gamma delta intraepithelial lymphocytes were isolated from the colons of DSS-treated and untreated mice. Total RNAs were isolated and compared by Affymetrix DNA microarray. Duplicate comparisons were made between DSS-treated and untreated gamma delta intraepithelial lymphocytes.

ORGANISM(S): Mus musculus

SUBMITTER: Lora Hooper

PROVIDER: E-GEOD-13946 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Similar Datasets

Comparison of gamma delta intraepithelial lymphocytes from DSS-treated and untreated colon

Project description:gamma delta intraepithelial lymphocytes were isolated from the colons of DSS-treated and untreated mice. Total RNAs were isolated and compared by Affymetrix DNA microarray.

2008-12-18 | GSE13946 | GEO

Mus musculus

Project description:Comparison of gamma delta intraepithelial lymphocytes from DSS-treated and untreated colon

| PRJNA110281 | ENA

Expression data from mouse small intestinal γδ intraepithelial lymphocytes

Project description:The mammalian gastrointestinal tract harbors thousands of bacterial species that include symbionts as well as potential pathogens. The immune responses that limit access of these bacteria to underlying tissue remain poorly defined. In this study, we used microarrays to uncover the transcriptional responses that occur in small intestinal γδ intraepithelial lymphocytes following bacterial challenge. γδ intraepithelial lymphocytes (γδ IEL) were isolated by flow cytometry from the small intestines of germ-free mice, or from age- and sex-matched conventionally-raised counterparts. We extracted RNAs from these purified γδ IEL for analysis on Affymetrix DNA microarrays. The mice were all >8 weeks in age, and each sample represents a pool of RNAs from 5-8 mice.

2011-04-06 | E-GEOD-28437 | biostudies-arrayexpress

Murine gamma delta intraepithelial lymphocyte response to type I IFN and TCR blockade

Project description:Interferon alpha (IFNa) is a pro-inflammatory cytokine that is rapidly upregulated as part of an innate immune response. Gamma delta intraepithelial lymphocytes (gd IEL) mount a rapid antimicrobial response to luminal microorganisms and previous report indicate that the T cell receptor (TCR) of these cells is constantly triggered at steady-state. We assessed the contribution of tonic TCR activation in response to acute, systemic IFNa administration among murine gd IELs. Our data demonstrate that inhibiting basal TCR signaling has a minimal effect on the transcriptional profile of gd IELs and acute IFNa exposure induces antiviral gene programs independent of TCR signaling.

2024-10-01 | GSE262121 | GEO

Transcriptome comparison between TCR γδ T subsets reveals their exclusive and shared markers

Project description:Intestinal intraepithelial gamma-delta T cells (iIEL gd T cells) constitute a peculiar subset of T lymphocytes located in the gut epithelial barrier involved in intestinal homeostasis. To date, type 1 and type 17 TCR gamma-delta T cells have been well characterized into two functional categories based on phenotypic and functional markers e.g. CD44 and CD27. However, It remains to be determined how to classify iIEL gamma T cells based on commonly used markers. We addressed this question by comparing the transcriptomes of mouse iIEL gamma-delta T cells with distinct functionally well-described gamma-delta T cells present in the periphery.

2022-06-29 | GSE198703 | GEO

Murine gamma delta intraepithelial lymphocyte response to type I IFN and TCR blockade

Project description:Murine gamma delta intraepithelial lymphocyte response to type I IFN and TCR blockade

| PRJNA1090425 | ENA

Bulk RNA sequencing of epithelial cells from AOM-DSS mouse colorectal cancer (CRC)

Project description:Gamma-delta T cells prevent CRC. To understand the criticial role of Gamma-delta T cells in CRC, AOM-DSS tumors from mice lacking TCRγδ and with TCRγδ cells were used to isolate epithelial cells to study gene expression by bulk RNA sequencing.

2023-10-06 | GSE202689 | GEO

Genome-wide maps of chromatin state in mouse small intestinal intraepithelial lymphocytes.

Project description:We performed CUT&Tag-Seq against histone H3K27me3 in mouse small intestinal TCRβ+CD8αα+ intraepithelial lymphocytes (IELs) of wild-type mice to analyze epigenetic modifications.

2022-08-02 | GSE185798 | GEO

Aiolos modulates IL-15 responsiveness of intestinal intraepithelial lymphocytes

Project description:Aiolos modulates IL-15 responsiveness of intestinal intraepithelial lymphocytes

| PRJNA908085 | ENA

Expression data from mouse small intestinal γδ intraepithelial lymphocytes

2011-04-06 | GSE28437 | GEO