Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human breast cancer metastases

ABSTRACT: Comparisons among breast cancer metastases at different organs revealed distinct microenvironments as characterized by cytokine content. Such microenvironment distinction might be important to dictate how the cancer cells adapt to survival before they successfully colonize. Experiment Overall Design: 58 breast cancer metastases from different organs were profiled and compared by the expression level of over 400 cytokines. 29 samples were incuded in this series. 29 others as well as 7 in the present series were profiled on U133A platforms and included in series GSE14018.

ORGANISM(S): Homo sapiens

SUBMITTER: Xiang Zhang 

PROVIDER: E-GEOD-14017 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Latent bone metastasis in breast cancer tied to Src-dependent survival signals.

Zhang Xiang H-F XH   Wang Qiongqing Q   Gerald William W   Hudis Clifford A CA   Norton Larry L   Smid Marcel M   Foekens John A JA   Massagué Joan J  

Cancer cell 20090701 1

Metastasis may arise years after removal of a primary tumor. The mechanisms allowing latent disseminated cancer cells to survive are unknown. We report that a gene expression signature of Src activation is associated with late-onset bone metastasis in breast cancer. This link is independent of hormone receptor status or breast cancer subtype. In breast cancer cells, Src is dispensable for homing to the bones or lungs but is critical for the survival and outgrowth of these cells in the bone marro  ...[more]

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