Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Toshiaki Watanabe
PROVIDER: E-GEOD-14095 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20110601 6
<h4>Purpose</h4>FOLFOX (a combination of leucovorin, fluorouracil and oxaliplatin) has achieved substantial success in the treatment of colorectal cancer (CRC) patients. However, about half of all patients show resistance to this regimen and some develop adverse symptoms such as neurotoxicity. In order to select patients who would benefit most from this therapy, we aimed to build a predictor for the response to FOLFOX using microarray gene expression profiles of primary CRC samples.<h4>Patients ...[more]