Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Phillip George Febbo
PROVIDER: E-GEOD-1413 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Majumder Pradip K PK Febbo Phillip G PG Bikoff Rachel R Berger Raanan R Xue Qi Q McMahon Louis M LM Manola Judith J Brugarolas James J McDonnell Timothy J TJ Golub Todd R TR Loda Massimo M Lane Heidi A HA Sellers William R WR
Nature medicine 20040523 6
Loss of PTEN function leads to activation of phosphoinositide 3-kinase (PI3K) signaling and Akt. Clinical trials are now testing whether mammalian target of rapamycin (mTOR) inhibition is useful in treating PTEN-null cancers. Here, we report that mTOR inhibition induced apoptosis of epithelial cells and the complete reversal of a neoplastic phenotype in the prostate of mice expressing human AKT1 in the ventral prostate. Induction of cell death required the mitochondrial pathway, as prostate-spec ...[more]