Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Hiroki Yamaguchi
PROVIDER: E-GEOD-14236 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Yamaguchi Hiroki H Hanawa Hideki H Uchida Naoya N Inamai Mitsuharu M Sawaguchi Kazuhiro K Mitamura Yoshio Y Shimada Takashi T Dan Kazuo K Inokuchi Koiti K
Experimental hematology 20090601 6
<h4>Objective</h4>Concerning MLL-AF4 leukemogenesis, previous mouse models suggest that the tumorigenesis capacity of MLL-AF4 alone is insufficient for causing leukemia. Based on the finding that an Fms-like tyrosine kinase 3 (Flt3) gene mutation in the tyrosine kinase domain (TKD) was observed in approximately 15% of mixed lineage leukemia (MLL), we investigated synergistic leukemogenesis effects of the two genes in vitro.<h4>Materials and methods</h4>In a mouse interleukin-3 (IL-3)-dependent c ...[more]