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Human nasopharyngeal carcinoma

ABSTRACT: To uncover the oncogenic pathways of nasopharyngeal carcinoma, gene expression profiles of primary NPC cell strains and NPC-derived cell lines were conducted and analyzed in depth. Keywords: Oncogenesis Gene expression profiles of 9 primary NPC cell strains and 5 NPC-derived cell lines were analyzed. Forty Î¼g total RNA from one NPC sample was needed for a dye-swap experiment. Total RNA from 32 normal nasopharyngeal epithelial cell strains was pooled to serve as a universal reference.

ORGANISM(S): Homo sapiens

SUBMITTER: Jyh-Lyh Juang

PROVIDER: E-GEOD-14262 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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G(alpha)12-mediated pathway promotes invasiveness of nasopharyngeal carcinoma by modulating actin cytoskeleton reorganization.

Liu Shu-Chen SC Jen Yee-Min YM Jiang Shih Sheng SS Chang Junn-Liang JL Hsiung Chao A CA Wang Chih-Hung CH Juang Jyh-Lyh JL

Cancer research 20090714 15

The molecular mechanisms behind the aggressiveness of nasopharyngeal carcinoma (NPC), a highly invasive and metastatic head and neck malignancy, have not been made clear. In this study investigating these mechanisms, guanine nucleotide-binding protein alpha(12) subunit (G(alpha)(12)) signaling was found by microarray analysis to be increased in primary NPC cells and NPC-derived cell lines. Using small interfering RNA to knock down G(alpha)(12) in NPC cells resulted in a reduction in cell migrati ...[more]

PMID: 19602597

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