Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Dean Tantin
PROVIDER: E-GEOD-14283 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Kang Jinsuk J Gemberling Matthew M Nakamura Mitsuhiro M Whitby Frank G FG Handa Hiroshi H Fairbrother William G WG Tantin Dean D
Genes & development 20090101 2
Oct1 and Oct4 are homologous transcription factors with similar DNA-binding specificities. Here we show that Oct1 is dynamically phosphorylated in vivo following exposure of cells to oxidative and genotoxic stress. We further show that stress regulates the selectivity of both proteins for specific DNA sequences. Mutation of conserved phosphorylation target DNA-binding domain residues in Oct1, and Oct4 confirms their role in regulating binding selectivity. Using chromatin immunoprecipitation, we ...[more]