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ArrayCGH of human hepatocellular carcinoma (HCC)

ABSTRACT: We used array-based comparative genomic hybridization (arrayCGH) of 76 hepatocellular carcinomas (HCCs) to search for genetically disrupted genes. Seventy-six HCC clinical specimens were analyzed. Genomic DNA of the tumor sample was labeled with Cy5 and reference normal DNA (Promega) was labeled with Cy3.

ORGANISM(S): Homo sapiens

SUBMITTER: Xin Wang

PROVIDER: E-GEOD-14322 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Integrative genomic identification of genes on 8p associated with hepatocellular carcinoma progression and patient survival.

Roessler Stephanie S Long Ezhou Lori EL Budhu Anuradha A Chen Yidong Y Zhao Xuelian X Ji Junfang J Walker Robert R Jia Hu-Liang HL Ye Qing-Hai QH Qin Lun-Xiu LX Tang Zhao-You ZY He Ping P Hunter Kent W KW Thorgeirsson Snorri S SS Meltzer Paul S PS Wang Xin Wei XW

Gastroenterology 20111224 4

<h4>Background & aims</h4>Hepatocellular carcinoma (HCC) is an aggressive malignancy; its mechanisms of development and progression are poorly understood. We used an integrative approach to identify HCC driver genes, defined as genes whose copy numbers associate with gene expression and cancer progression.<h4>Methods</h4>We combined data from high-resolution, array-based comparative genomic hybridization and transcriptome analysis of HCC samples from 76 patients with hepatitis B virus infection ...[more]

PMID: 22202459

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