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Transcription profiling of mouse retinal gene expression after hypoxic preconditioning identifies candidate genes for neuroprotection


ABSTRACT: Neuroprotective therapies for retinal degeneration may be used to rescue retinal cells and preserve vision. Hypoxic preconditioning stabilizes the transcription factor HIF-1α in the retina and strongly protects photoreceptors in an animal model of light-induced retinal degeneration. Our data suggest that neuroprotection after hypoxic preconditioning of the retina is the result of the differential expression of a multitude of genes which may act in concert to protect visual cells against a toxic insult. Experiment Overall Design: In total 24 samples were analyzed on Affymetrix mouse 430.2 arrays, the samples represent different durations of regeneration (none = 0 h, 2 h, 4 h and 16 h) from hypoxic or normoxic treatments, that were tested in triplicates.

ORGANISM(S): Mus musculus

SUBMITTER: Wolfgang Raffelsberger 

PROVIDER: E-GEOD-14366 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Analysis of the retinal gene expression profile after hypoxic preconditioning identifies candidate genes for neuroprotection.

Thiersch Markus M   Raffelsberger Wolfgang W   Frigg Rico R   Samardzija Marijana M   Wenzel Andreas A   Poch Olivier O   Grimm Christian C  

BMC genomics 20080208


<h4>Background</h4>Retinal degeneration is a main cause of blindness in humans. Neuroprotective therapies may be used to rescue retinal cells and preserve vision. Hypoxic preconditioning stabilizes the transcription factor HIF-1alpha in the retina and strongly protects photoreceptors in an animal model of light-induced retinal degeneration. To address the molecular mechanisms of the protection, we analyzed the transcriptome of the hypoxic retina using microarrays and real-time PCR.<h4>Results</h  ...[more]

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