Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Wolfgang Raffelsberger
PROVIDER: E-GEOD-14366 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Thiersch Markus M Raffelsberger Wolfgang W Frigg Rico R Samardzija Marijana M Wenzel Andreas A Poch Olivier O Grimm Christian C
BMC genomics 20080208
<h4>Background</h4>Retinal degeneration is a main cause of blindness in humans. Neuroprotective therapies may be used to rescue retinal cells and preserve vision. Hypoxic preconditioning stabilizes the transcription factor HIF-1alpha in the retina and strongly protects photoreceptors in an animal model of light-induced retinal degeneration. To address the molecular mechanisms of the protection, we analyzed the transcriptome of the hypoxic retina using microarrays and real-time PCR.<h4>Results</h ...[more]