Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Gene expression analysis in gut biopsies of Crohn's Disease patients and patients with Spondylarthropathy

ABSTRACT: A focussed microarray chip was constructed specifically for studying basal colonic gene expression in patients with Spondyloarthropathy (SpA) and Crohn's disease (CD) (ref: PMID 16476712). These focus microarrays were used 1) to study common changes in gene expression between SpA and CD, providing early markers in the follow-up study of patients with SpA and particularly these patients that evolve into clinically overt CD; and 2) to identify new candidate genes for CD by integrating gene expression data with genetic information. Keywords: Crohn's Disease, Spondylarthropathy, biopsies This experiment was done in a dye-swap design in which all samples of interest were compared to a pooled sample.

ORGANISM(S): Homo sapiens

SUBMITTER: Joke Allemeersch

PROVIDER: E-GEOD-14442 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Altered gut transcriptome in spondyloarthropathy.

Laukens D D Peeters H H Cruyssen B V BV Boonefaes T T Elewaut D D De Keyser F F Mielants H H Cuvelier C C Veys E M EM Knecht K K Van Hummelen P P Remaut E E Steidler L L De Vos M M Rottiers P P

Annals of the rheumatic diseases 20060213 10

<h4>Background</h4>Intestinal inflammation is a common feature of spondyloarthropathy (SpA) and Crohn's disease. Inflammation is manifested clinically in Crohn's disease and subclinically in SpA. However, a fraction of patients with SpA develops overt Crohn's disease.<h4>Aims</h4>To investigate whether subclinical gut lesions in patients with SpA are associated with transcriptome changes comparable to those seen in Crohn's disease and to examine global gene expression in non-inflamed colon biops ...[more]

PMID: 16476712

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Dataset Information

Gene expression analysis in gut biopsies of Crohn's Disease patients and patients with Spondylarthropathy

Publications

Altered gut transcriptome in spondyloarthropathy.

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