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Transcription profiling of human U266, MM.1s, KMS11, 8226/S multiple myeloma cell lines treated with arsenic

ABSTRACT: We used microarrays to examine changes in gene expression in multiple myeloma cell lines following treatment with arsenic trioxide and darinaparsin Experiment Overall Design: Four multiple myeloma cell lines (U266, MM.1s, KMS11, 8226/S) were treated with either arsenic trioxide (ATO) for 6, 24, or 48 hours or darinaparsin (DAR) for 6 or 24 hours; RNA was extracted from treated and control cells for microarray analysis

ORGANISM(S): Homo sapiens

SUBMITTER: Larry Boise

PROVIDER: E-GEOD-14519 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Darinaparsin induces a unique cellular response and is active in an arsenic trioxide-resistant myeloma cell line.

Matulis Shannon M SM Morales Alejo A AA Yehiayan Lucy L Croutch Claire C Gutman Delia D Cai Yong Y Lee Kelvin P KP Boise Lawrence H LH

Molecular cancer therapeutics 20090505 5

Here, we report on the organic arsenical darinaparsin (ZIO-101, S-dimethylarsino-glutathione) and its anti-myeloma activity compared with inorganic arsenic trioxide. Darinaparsin induced apoptosis in multiple myeloma cell lines in a dose-dependent manner, and the addition of N-acetylcysteine, which increases intracellular glutathione (GSH), blocked cytotoxicity of both darinaparsin and arsenic trioxide. In contrast to arsenic trioxide, intracellular GSH does not appear to be important for darina ...[more]

PMID: 19417148

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human leukemia cell line K562 offspring acquring imatinib resistance(K562-r) : Control vs. Drug treated

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2010-12-30 | E-GEOD-24946 | biostudies-arrayexpress

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2018-10-16 | PXD010224 | Pride

Comparison of gene expression profile of naive versus arsenic trioxide resistant acute promyelocytic leukemia cell line NB4

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