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Transcription profiling of mouse macrophage response to LPS

ABSTRACT: RAW264.7 murine macrophages treated with LPS

ORGANISM(S): Mus musculus

SUBMITTER: Rachael Zoe Murray

PROVIDER: E-GEOD-1459 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Syntaxin 6 and Vti1b form a novel SNARE complex, which is up-regulated in activated macrophages to facilitate exocytosis of tumor necrosis Factor-alpha.

Murray Rachael Z RZ Wylie Fiona G FG Khromykh Tatiana T Hume David A DA Stow Jennifer L JL

The Journal of biological chemistry 20050107 11

A key function of activated macrophages is to secrete proinflammatory cytokines such as TNFalpha; however, the intracellular pathway and machinery responsible for cytokine trafficking and secretion is largely undefined. Here we show that individual SNARE proteins involved in vesicle docking and fusion are regulated at both gene and protein expression upon stimulation with the bacterial cell wall component lipopolysaccharide. Focusing on two intracellular SNARE proteins, Vti1b and syntaxin 6 (Stx ...[more]

PMID: 15640147

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