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Uranyl nitrate exposure

ABSTRACT: SAGE analysis in kidney obtained from control mice or after acute or chronic exposure to uranyl nitrate (UN). Keywords: other

ORGANISM(S): Mus musculus

SUBMITTER: Magali Taulan

PROVIDER: E-GEOD-1465 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Renal toxicogenomic response to chronic uranyl nitrate insult in mice.

Taulan Magali M Paquet François F Maubert Christophe C Delissen Olivia O Demaille Jacques J Romey Marie-Catherine MC

Environmental health perspectives 20041101 16

Although the nephrotoxicity of uranium has been established through numerous animal studies, relatively little is known about the effects of long-term environmental uranium exposure. Using a combination of conventional biochemical studies and serial analysis of gene expression (SAGE), we examined the renal responses to uranyl nitrate (UN) chronic exposure. Renal uranium levels were significantly increased 4 months after ingestion of uranium in drinking water. Creatinine levels in serum were slig ...[more]

PMID: 15598614

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uranyl nitrate exposure

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