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Transcription profiling of human CD4-positive cells purified from peripheral blood of ATL patients

ABSTRACT: CD4-positive cells purified from peripheral blood of ATL patients.

ORGANISM(S): Homo sapiens

SUBMITTER: Hiroyuki Mano

PROVIDER: E-GEOD-1466 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A genomic analysis of adult T-cell leukemia.

Choi Y L YL Tsukasaki K K O'Neill M C MC Yamada Y Y Onimaru Y Y Matsumoto K K Ohashi J J Yamashita Y Y Tsutsumi S S Kaneda R R Takada S S Aburatani H H Kamihira S S Nakamura T T Tomonaga M M Mano H H

Oncogene 20060814 8

Adult T-cell leukemia (ATL) is an intractable malignancy of CD4+ T cells that is etiologically associated with infection by human T-cell leukemia virus-type I. Most individuals in the chronic stage of ATL eventually undergo progression to a highly aggressive acute stage. To clarify the mechanism responsible for this stage progression, we isolated CD4+ cells from individuals in the chronic (n=19) or acute (n=22) stages of ATL and subjected them to profiling of gene expression with DNA microarrays ...[more]

PMID: 16909099

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