Dataset Information
Computational and Analytical Framework for Small RNA Profiling by High-Throughput Sequencing
Ontology highlight
ABSTRACT:
ORGANISM(S): Arabidopsis thaliana
SUBMITTER: James Carrington
PROVIDER: E-GEOD-14696 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Computational and analytical framework for small RNA profiling by high-throughput sequencing.
RNA (New York, N.Y.) 20090323 5
The advent of high-throughput sequencing (HTS) methods has enabled direct approaches to quantitatively profile small RNA populations. However, these methods have been limited by several factors, including representational artifacts and lack of established statistical methods of analysis. Furthermore, massive HTS data sets present new problems related to data processing and mapping to a reference genome. Here, we show that cluster-based sequencing-by-synthesis technology is highly reproducible as ...[more]
