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Steroid Pretreatment of Organ Donors to Prevent Postischemic Renal Allograft Failure: A Randomized, Controlled Trial


ABSTRACT: Comparison between pretreated donor grafts corticosteroid vs. placebo Prospective, randomised, double-blind, placebo-control trial, xls files contain normalized data (Default Total Intensity Normalization, see Stanford Microarray Database website), gpr files the raw data

ORGANISM(S): Homo sapiens

SUBMITTER: Julia Wilflingseder 

PROVIDER: E-GEOD-14700 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Steroid pretreatment of organ donors to prevent postischemic renal allograft failure: a randomized, controlled trial.

Kainz Alexander A   Wilflingseder Julia J   Mitterbauer Christa C   Haller Maria M   Burghuber Christopher C   Perco Paul P   Langer Robert M RM   Heinze Georg G   Oberbauer Rainer R  

Annals of internal medicine 20100801 4


<h4>Background</h4>Posttransplantation acute renal failure (ARF) occurs in roughly 25% of recipients of organs from deceased donors. Inflammation in the donor organ is associated with risk for ARF.<h4>Objective</h4>To determine whether administering corticosteroids to deceased organ donors reduces the incidence and duration of ARF in organ recipients more than placebo.<h4>Design</h4>Parallel, blocked randomized trial, performed between February 2006 and November 2008, with computer-generated ran  ...[more]

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