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Transcription profiling of Caco-2 and T84 human cell lines treated with flagellin, lymphotox beta or TNF alpha

ABSTRACT: 14 day old Caco-2 and T84 cells were treated for 4 hours with flagellin, lymphotox beta or TNF alpha, respectively, and their expression profile compared to non-stimulated cells.

ORGANISM(S): Homo sapiens

SUBMITTER: Pascale Anderle

PROVIDER: E-GEOD-1474 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Caco-2 and T84 cells stimulated with with flagellin, lymphotox beta or TNF alpha

Project description:14 day old Caco-2 and T84 cells were treated with flagellin, lymphotox beta or TNF alpha, respectively, and their expression profile compared to non-stimulated cells. Keywords: other

2004-06-16 | GSE1474 | GEO

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Homo sapiens

Project description:Caco-2 and T84 cells stimulated with with flagellin, lymphotox beta or TNF alpha

| PRJNA90061 | ENA

flagellin

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Re-annotated role of beta-Galactosidase in Flagellin deglycosylation

Project description:Most Eukaryotes recognise flagellin as a signature of bacterial invasion. In contrast to animals, plants do not recognise flagellin proteins, but conserved peptides released from flagellin (Felix et al., 1999). However, these peptides (e.g. flg22) are folded and buried deeply inside the flagellin polymer and would need to be released before they can interact with cell surface receptors, such as FLS2 (Fliegman & Felix, 2016). Here we discovered that the hydrolytic pathway releasing the flagellin elicitor in plants is initiated by a host-secreted beta-galactosidase (BGAL), which removes the terminal modified viosamine (mVio) from the O-glycan that cloaks the flagellin polymer. BGAL contributes to flagellin-dependent immunity but only against bacterial Pseudomonas syringae strains that carry mVio. Signatures of arms races at this new level of antagonistic interactions are that BGAL is suppressed during infection by a heat stable metabolite secreted by bacteria, and that other P. syringae strains carry BGAL-insensitive O-glycans.

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