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Gene Expression Profiles of Pregnant and Non-pregnant Whole Blood

ABSTRACT: Comparison of gene expression profiles in whole blood collected from pregnant and non-pregnant females. Peripheral whole blood samples from 5 third trimester pregnant females and 5 non-pregnant females were collected. The gene expression profiles of the two groups were compared using Affymetrix HG-U133A and HG-U133B array sets.

ORGANISM(S): Homo sapiens

SUBMITTER: Yuk Ming Lo

PROVIDER: E-GEOD-14771 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Placenta-derived fetal specific mRNA is more readily detectable in maternal plasma than in whole blood.

Heung Macy M S MM Jin Shengnan S Tsui Nancy B Y NB Ding Chunming C Leung Tak Y TY Lau Tze K TK Chiu Rossa W K RW Lo Y M Dennis YM

PloS one 20090610 6

<h4>Background</h4>Placental mRNA was detected in maternal whole blood, raising the possibility of using maternal blood for noninvasive prenatal diagnosis. We investigated fetal mRNA detection in maternal whole blood and determined if it offered advantages over maternal plasma analysis.<h4>Methodology</h4>The concentrations of placental expressed genes, CSH1, KISS1, PLAC4 and PLAC1 in plasma and whole blood from healthy pregnant and non-pregnant individuals were compared by real-time quantitativ ...[more]

PMID: 19516908

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