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Transcription profiling of human hematopoietic stem cell subpopulations

ABSTRACT: Hematopoietic stem cell (HSC) subsets based on the CD34 expression and/or lineage markers expression

ORGANISM(S): Homo sapiens

SUBMITTER: Rossella Manfredini

PROVIDER: E-GEOD-1493 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The kinetic status of hematopoietic stem cell subpopulations underlies a differential expression of genes involved in self-renewal, commitment, and engraftment.

Manfredini Rossella R Zini Roberta R Salati Simona S Siena Michela M Tenedini Elena E Tagliafico Enrico E Montanari Monica M Zanocco-Marani Tommaso T Gemelli Claudia C Vignudelli Tatiana T Grande Alexis A Fogli Miriam M Rossi Lara L Fagioli Maria Elena ME Catani Lucia L Lemoli Roberto M RM Ferrari Sergio S

Stem cells (Dayton, Ohio) 20050401 4

The gene expression profile of CD34(-) hematopoietic stem cells (HSCs) and the correlations with their biological properties are still poorly understood. To address this issue, we used the DNA microarray technology to compare the expression profiles of different peripheral blood hemopoietic stem/progenitor cell subsets, lineage-negative (Lin(-)) CD34(-), Lin(-)CD34(+), and Lin(+)CD34(+) cells. The analysis of gene categories differentially expressed shows that the expression of CD34 is associate ...[more]

PMID: 15790771

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