Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Expression data from ERBB2 over-expression and EGF stimulation in MCF10A cells


ABSTRACT: Expression data from ERBB2 over-expression and EGF stimulation in MCF10A cells The cells were transduced with retroviruses encoding vector control (pBabe) or pBabe-ErbB2. After infection cells were switched to assay medium supplemented with only 2% horse serum and no EGF. For EGF stimulation, cells transduced with empty vector were treated with EGF at 50 ng/ml for 2 hours before harvesting.

ORGANISM(S): Homo sapiens

SUBMITTER: Ben Wittner 

PROVIDER: E-GEOD-14987 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Gene expression signatures are used in the clinic as prognostic tools to determine the risk of individual patients with localized breast tumors developing distant metastasis. We lack a clear understanding, however, of whether these correlative biomarkers link to a common biological network that regulates metastasis. We find that the c-MYC oncoprotein coordinately regulates the expression of 13 different "poor-outcome" cancer signatures. In addition, functional inactivation of MYC in human breast  ...[more]

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