Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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ChIP-on-chip of BCL6


ABSTRACT: Identification BCL6 target genes in primary germinal center cells and DLBCL cell lines by ChIP-on-chip Three replicates in each type of cells

ORGANISM(S): Homo sapiens

SUBMITTER: weimin ci 

PROVIDER: E-GEOD-15179 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL.

Ci Weimin W   Polo Jose M JM   Cerchietti Leandro L   Shaknovich Rita R   Wang Ling L   Yang Shao Ning SN   Ye Kenny K   Farinha Pedro P   Horsman Douglas E DE   Gascoyne Randy D RD   Elemento Olivier O   Melnick Ari A  

Blood 20090323 22


The BCL6 transcriptional repressor is required for development of germinal center (GC) B cells and when expressed constitutively causes diffuse large B-cell lymphomas (DLBCLs). We examined genome-wide BCL6 promoter binding in GC B cells versus DLBCLs to better understand its function in these settings. BCL6 bound to both distinct and common sets of functionally related gene in normal GC cells versus DLBCL cells. Certain BCL6 target genes were preferentially repressed in GC B cells, but not DLBCL  ...[more]

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