Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: weimin ci
PROVIDER: E-GEOD-15179 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Ci Weimin W Polo Jose M JM Cerchietti Leandro L Shaknovich Rita R Wang Ling L Yang Shao Ning SN Ye Kenny K Farinha Pedro P Horsman Douglas E DE Gascoyne Randy D RD Elemento Olivier O Melnick Ari A
Blood 20090323 22
The BCL6 transcriptional repressor is required for development of germinal center (GC) B cells and when expressed constitutively causes diffuse large B-cell lymphomas (DLBCLs). We examined genome-wide BCL6 promoter binding in GC B cells versus DLBCLs to better understand its function in these settings. BCL6 bound to both distinct and common sets of functionally related gene in normal GC cells versus DLBCL cells. Certain BCL6 target genes were preferentially repressed in GC B cells, but not DLBCL ...[more]