Ontology highlight
ABSTRACT:
ORGANISM(S): Drosophila melanogaster
SUBMITTER: Colin Malone
PROVIDER: E-GEOD-15186 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Malone Colin D CD Brennecke Julius J Dus Monica M Stark Alexander A McCombie W Richard WR Sachidanandam Ravi R Hannon Gregory J GJ
Cell 20090423 3
In Drosophila gonads, Piwi proteins and associated piRNAs collaborate with additional factors to form a small RNA-based immune system that silences mobile elements. Here, we analyzed nine Drosophila piRNA pathway mutants for their impacts on both small RNA populations and the subcellular localization patterns of Piwi proteins. We find that distinct piRNA pathways with differing components function in ovarian germ and somatic cells. In the soma, Piwi acts singularly with the conserved flamenco pi ...[more]