Effect of imatinib on FIP1L1-PDGFRA-expressing EOL1 cells
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ABSTRACT: The Eol1 cell line has been derived from a patient with chronic eosiniphilic leukemia. Eol1 cells express the FIP1L1-PDGFRalpha oncogene. Inhibition of FIP1L1-PDGFRalpha with imatinib mesylate (Glivec) blocks proliferation and survival of the cells. We performed microarray expression analysis to identify genes specifically regulated by FIP1L1-PDGFRalpha using imatinib-treated cells as baseline. The list of regulated genes was consistent with the activation of STAT trancription factors by FIP1L1-PDGFRA. Keywords: 4 hours treatment with Glivec Eol1 cells were cultured in presence or absence of Glivec for 4 hours before RNA extraction and hybridization on Affymetrix microarray.
ORGANISM(S): Homo sapiens
SUBMITTER: Federica Toffalini
PROVIDER: E-GEOD-15237 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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