Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Hironori Matsushima
PROVIDER: E-GEOD-15360 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Matsushima Hironori H Tanaka Hiroaki H Mizumoto Norikatsu N Takashima Akira A
Blood 20090428 1
By screening 720 natural compounds in a standard 2-way allogeneic mixed leukocyte reaction assay, we identified a potent immunosuppressive capacity of crassin acetate (CRA), a coral-derived cembrane diterpenoid. CRA efficiently inhibited allogeneic mixed leukocyte reaction as well as antigen-specific activation of CD4 T cells by bone marrow-derived dendritic cells (DCs). With regard to cellular targets, CRA suppressed not only mitogen-triggered T-cell activation, but also lipopolysaccharide-indu ...[more]