Chronic Hypoxia predicts Poor Prognosis in Hepatocellular Carcinoma

ABSTRACT: Background - Hepatocellular carcinomas (HCCs) are heterogeneous tumors with respect to etiology, cell of origin and biology. The course of the disease is unpredictable and is in part dependent on the tumor microenvironment. One of the microenvironmental factors is hypoxia, which is known to promote aggressiveness in other malignant tumors. We hypothesized that certain regions in HCC exist with chronic hypoxia and a characteristic gene expression pattern. Moreover, during the development of HCC there is an important contribution of this chronic hypoxia on prognosis via this gene expression. Until now, most research has been performed in acute hypoxic models (< 24 hours). Methods – Human hepatoblastoma cells HepG2 were cultured in either normoxic (20% O2) or hypoxic (2% O2) conditions for 72

ORGANISM(S): Homo sapiens

SUBMITTER: Joke Allemeersch 

PROVIDER: E-GEOD-15366 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress