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Array CGH analysis of 56 primary gastric cancers for elucidating prognostic biomarkers

ABSTRACT: Array CGH analysis was done with 56 primary gastric cancers to elucidate prognostic biomarkers on the BAC basis. Using the extracted genomic DNA from 56 primary gastric cancers, array CGH was done to elucidate the prognostic biomarkers.

ORGANISM(S): Homo sapiens

SUBMITTER: Nobumoto Tomioka 

PROVIDER: E-GEOD-15436 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Array comparative genomic hybridization analysis revealed four genomic prognostic biomarkers for primary gastric cancers.

Tomioka Nobumoto N   Morita Keiko K   Kobayashi Nozomi N   Tada Mitsuhiro M   Itoh Tomoo T   Saitoh Soichiro S   Kondo Masao M   Takahashi Norihiko N   Kataoka Akihiko A   Nakanishi Kazuaki K   Takahashi Masato M   Kamiyama Toshiya T   Ozaki Michitaka M   Hirano Takashi T   Todo Satoru S  

Cancer genetics and cytogenetics 20100801 1

Unlike the case with some other solid tumors, whole genome array screening has not revealed prognostic genetic aberrations in primary gastric cancer. Comparative genomic hybridization (CGH) using bacterial artificial chromosome (BAC) arrays for 56 primary gastric cancers resulted in identification of four prognostic loci in this study: 6q21 (harboring FOXO3A; previously FKHRL1), 9q32 (UGCG), 17q21.1 approximately q21.2 (CASC3), and 17q21.32 (HOXB3 through HOXB9). If any one of these four loci wa  ...[more]

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