Transcription profiling of human gastric cancers (Gastric Cancer project - Singapore Patient Cohort)

ABSTRACT: Genome-wide mRNA expression profiles of 200 primary gastric tumors from the Singapore patient cohort. Gastric cancer (GC) is the second leading cause of global cancer mortality, with individual gastric tumors displaying significant heterogeneity in their deregulation of various oncogenic pathways. We aim to identify major oncogenic pathways in GC that robustly impact patient survival and treatment response. We used an in silico strategy based on gene expression signatures and connectivity analytics to map patterns of oncogenic pathway activation in 25 unique GC cell lines, and in 301 primary gastric cancers from three independent patient cohorts. Of 11 oncogenic pathways previously implicated in GC, we identified three predominant pathways (proliferation/stem cell, NF-kB, and Wnt/b-catenin

ORGANISM(S): Homo sapiens

SUBMITTER: Chia-Huey Ooi 

PROVIDER: E-GEOD-15459 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress