Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Robert Strauss
PROVIDER: E-GEOD-15473 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Strauss Robert R Sova Pavel P Liu Ying Y Li Zong Yi ZY Tuve Sebastian S Pritchard David D Brinkkoetter Paul P Möller Thomas T Wildner Oliver O Pesonen Sari S Hemminki Akseli A Urban Nicole N Drescher Charles C Lieber André A
Cancer research 20090602 12
We studied the susceptibility of primary ovarian cancer cells to oncolytic adenoviruses. Using gene expression profiling of cancer cells either resistant or susceptible to viral oncolysis, we discovered that the epithelial phenotype of ovarian cancer represents a barrier to infection by commonly used oncolytic adenoviruses targeted to coxsackie-adenovirus receptor or CD46. Specifically, we found that these adenovirus receptors were trapped in tight junctions and not accessible for virus binding. ...[more]