Unknown,Transcriptomics,Genomics,Proteomics

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Resistance of primary ovarian cancer cells to oncolytic adenoviruses


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE15350: Resistance of primary ovarian cancer cells to oncolytic adenoviruses part1 of 2 GSE15351: Resistance of primary ovarian cancer cells to oncolytic adenoviruses part2 of 2 Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Robert Strauss 

PROVIDER: E-GEOD-15473 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


We studied the susceptibility of primary ovarian cancer cells to oncolytic adenoviruses. Using gene expression profiling of cancer cells either resistant or susceptible to viral oncolysis, we discovered that the epithelial phenotype of ovarian cancer represents a barrier to infection by commonly used oncolytic adenoviruses targeted to coxsackie-adenovirus receptor or CD46. Specifically, we found that these adenovirus receptors were trapped in tight junctions and not accessible for virus binding.  ...[more]

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