Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: D. Stephen Charnock-Jones
PROVIDER: E-GEOD-15494 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Araki Hiromitsu H Tamada Yoshinori Y Imoto Seiya S Dunmore Ben B Sanders Deborah D Humphrey Sally S Nagasaki Masao M Doi Atsushi A Nakanishi Yukiko Y Yasuda Kaori K Tomiyasu Yuki Y Tashiro Kousuke K Print Cristin C Charnock-Jones D Stephen DS Kuhara Satoru S Miyano Satoru S
Angiogenesis 20090409 3
Fenofibrate is a synthetic ligand for the nuclear receptor peroxisome proliferator-activated receptor (PPAR) alpha and has been widely used in the treatment of metabolic disorders, especially hyperlipemia, due to its lipid-lowering effect. The molecular mechanism of lipid-lowering is relatively well defined: an activated PPARalpha forms a PPAR-RXR heterodimer and this regulates the transcription of genes involved in energy metabolism by binding to PPAR response elements in their promoter regions ...[more]