Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Human umbilical vein endothelial cells (HUVECs) treated with fenofibrate


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE15482: The effect of PPARa siRNA on endothelial cells treated with fenofibrate GSE15483: The effect of fenofibrate on endothelial cells Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: D. Stephen Charnock-Jones 

PROVIDER: E-GEOD-15494 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Analysis of PPARalpha-dependent and PPARalpha-independent transcript regulation following fenofibrate treatment of human endothelial cells.

Araki Hiromitsu H   Tamada Yoshinori Y   Imoto Seiya S   Dunmore Ben B   Sanders Deborah D   Humphrey Sally S   Nagasaki Masao M   Doi Atsushi A   Nakanishi Yukiko Y   Yasuda Kaori K   Tomiyasu Yuki Y   Tashiro Kousuke K   Print Cristin C   Charnock-Jones D Stephen DS   Kuhara Satoru S   Miyano Satoru S  

Angiogenesis 20090409 3


Fenofibrate is a synthetic ligand for the nuclear receptor peroxisome proliferator-activated receptor (PPAR) alpha and has been widely used in the treatment of metabolic disorders, especially hyperlipemia, due to its lipid-lowering effect. The molecular mechanism of lipid-lowering is relatively well defined: an activated PPARalpha forms a PPAR-RXR heterodimer and this regulates the transcription of genes involved in energy metabolism by binding to PPAR response elements in their promoter regions  ...[more]

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