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Individualized analysis of subcutaneous and omental abdominal adipose tissue from non-obese and obese subjects

ABSTRACT: Individualized analysis through expression profiling of 20,000 probes in 28 tissue samples evaluated in subcutaneous and omental adipose tissue obtained during surgical intervention in non-obese and obese patients. Patients consisted of men and women of varying body size (lean to severely obese). Samples were collected at the time of operation in the fasting state. Samples consisted of subcutaneous and omental adipose tissue as well as a blood sample from lean and obese men and women removed in the fasting state at the time of surgery.

ORGANISM(S): Homo sapiens

SUBMITTER: Katherine Cianflone

PROVIDER: E-GEOD-15524 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Association of adipocyte genes with ASP expression: a microarray analysis of subcutaneous and omental adipose tissue in morbidly obese subjects.

MacLaren Robin E RE Cui Wei W Lu HuiLing H Simard Serge S Cianflone Katherine K

BMC medical genomics 20100127

<h4>Background</h4>Prevalence of obesity is increasing to pandemic proportions. However, obese subjects differ in insulin resistance, adipokine production and co-morbidities. Based on fasting plasma analysis, obese subjects were grouped as Low Acylation Stimulating protein (ASP) and Triglyceride (TG) (LAT) vs High ASP and TG (HAT). Subcutaneous (SC) and omental (OM) adipose tissues (n = 21) were analysed by microarray, and biologic pathways in lipid metabolism and inflammation were specifically ...[more]

PMID: 20105310

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