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Gene expression of pancreatic cancer cells

ABSTRACT: Global gene expression profiling on replicates of 9 pancreatic cancer cell lines (L3.6pl, BxPC3, CFPAC, SU8686, Panc-1, Hs766T, AsPC1, MIAPaca-2, MPanc 96) and normal HPDE cells was performed to elucidate multi-drug sensitivity/ resistance. Keywords: D microarray (Illumina human 2) Duplicates of 9 pancreatic cancer cell lines and 1 normal HPDE cell line were used. Microarray experiment and data analysis were done at Dept. of Urology, MDACC (Houston, USA).

ORGANISM(S): Homo sapiens

SUBMITTER: Woonyoung Choi

PROVIDER: E-GEOD-15550 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer.

Arumugam Thiruvengadam T Ramachandran Vijaya V Fournier Keith F KF Wang Huamin H Marquis Lauren L Abbruzzese James L JL Gallick Gary E GE Logsdon Craig D CD McConkey David J DJ Choi Woonyoung W

Cancer research 20090707 14

A better understanding of drug resistance mechanisms is required to improve outcomes in patients with pancreatic cancer. Here, we characterized patterns of sensitivity and resistance to three conventional chemotherapeutic agents with divergent mechanisms of action [gemcitabine, 5-fluorouracil (5-FU), and cisplatin] in pancreatic cancer cells. Four (L3.6pl, BxPC-3, CFPAC-1, and SU86.86) were sensitive and five (PANC-1, Hs766T, AsPC-1, MIAPaCa-2, and MPanc96) were resistant to all three agents bas ...[more]

PMID: 19584296

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