Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Chella David
PROVIDER: E-GEOD-15571 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Rajagopalan Govindarajan G Tilahun Ashenafi Y AY Asmann Yan W YW David Chella S CS
Physiological genomics 20090331 3
Toxic shock syndrome (TSS) is an acute, serious systemic illness caused by bacterial superantigens. Nonavailability of a suitable animal model until recently has hampered an in-depth understanding of the pathogenesis of TSS. In the current study, we characterized the early molecular events underlying TSS using our HLA-DR3 transgenic mouse model. Gene expression profiling using DNA microarrays identified a rapid and significant upregulation of several pro- as well as anti-inflammatory mediators, ...[more]