Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Charlotte Ng
PROVIDER: E-GEOD-15622 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Ahmed Ahmed Ashour AA Mills Anthony D AD Ibrahim Ashraf E K AE Temple Jillian J Blenkiron Cherie C Vias Maria M Massie Charlie E CE Iyer N Gopalakrishna NG McGeoch Adam A Crawford Robin R Nicke Barbara B Downward Julian J Swanton Charles C Bell Stephen D SD Earl Helena M HM Laskey Ronald A RA Caldas Carlos C Brenton James D JD
Cancer cell 20071201 6
The extracellular matrix (ECM) can induce chemotherapy resistance via AKT-mediated inhibition of apoptosis. Here, we show that loss of the ECM protein TGFBI (transforming growth factor beta induced) is sufficient to induce specific resistance to paclitaxel and mitotic spindle abnormalities in ovarian cancer cells. Paclitaxel-resistant cells treated with recombinant TGFBI protein show integrin-dependent restoration of paclitaxel sensitivity via FAK- and Rho-dependent stabilization of microtubules ...[more]