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Transcription profiling of mouse Stat3flx/flx/NIC breast tumors compared to wild type NIC tumors

ABSTRACT: A Stat3-dependent transcription regulatory network involved in inflammation and metastasis is identified. Analyses of the gene expression data revealed that Stat3flx/flx/NIC tumors exhibited a significant reduction in the expression of factors involved in both tumor angiogenesis (fibronectin, von willebrand factor, annexin a3, thrombopoietin, fibulin 5) and in the acute phase inflammatory response (cebpd, osmr, saa1, saa2) Experiment Overall Design: Common reference design. 8 samples including RNA extracted from 3 pools of Stat3wt/wt/NIC (WT) tumor tissues (5 individual tumor samples per pool) and 5 individual Stat3flx/flx/NIC (Homo) tumor tissue samples.

ORGANISM(S): Mus musculus

SUBMITTER: Solmaz Shahalizadeh 

PROVIDER: E-GEOD-15632 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Identification of a Stat3-dependent transcription regulatory network involved in metastatic progression.

Ranger Jill J JJ   Levy David E DE   Shahalizadeh Solmaz S   Hallett Michael M   Muller William J WJ  

Cancer research 20090818 17

High levels of activated Stat3 are often found in human breast cancers and can correlate with poor patient outcome. We employed an activated ErbB2 mouse model of breast cancer to investigate the in vivo role of Stat3 in mammary tumor progression and found that Stat3 does not alter mammary tumor initiation but dramatically affects metastatic progression. Four-fold fewer animals exhibited lung metastases in the absence of Stat3 and a 12-fold reduction in the number of lung lesions was observed in  ...[more]

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