Ontology highlight
ABSTRACT:
ORGANISM(S): Caenorhabditis elegans
SUBMITTER: Jae Kim
PROVIDER: E-GEOD-15656 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Jo Hyunsun H Shim Jiwon J Lee Jung Hyun JH Lee Junho J Kim Jae Bum JB
Cell metabolism 20090501 5
The endoplasmic reticulum (ER) is an organelle associated with lipid metabolism. However, the involvement of the ER in nutritional status-dependent energy homeostasis is largely unknown. We demonstrate that IRE-1, an ER protein known to be involved in the unfolded protein response, and HSP-4, an ER chaperone, regulate expression of the novel fasting-induced lipases FIL-1 and FIL-2, which induce fat granule hydrolysis upon fasting in C. elegans. RNAi and ectopic expression experiments demonstrate ...[more]