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Transcription profiling of rat freshly-isolated alveolar epithelial type I cells, freshly-isolated type II cells, and type II cells cultured for 7 days

ABSTRACT: Comparison of rat freshly-isolated alveolar epithelial type I cells, freshly-isolated type II cells, and type II cells cultured for 7 days

ORGANISM(S): Rattus norvegicus

SUBMITTER: Leland Dobbs

PROVIDER: E-GEOD-1567 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Freshly isolated rat alveolar type I cells, type II cells, and cultured type II cells have distinct molecular phenotypes.

Gonzalez Robert R Yang Yee Hwa YH Griffin Chandi C Allen Lennell L Tigue Zachary Z Dobbs Leland L

American journal of physiology. Lung cellular and molecular physiology 20040924 1

We used microarray analysis with Affymetrix rat chips to determine gene expression profiles of freshly isolated rat type I (TI) and TII cells and cultured TII cells. Our goals were 1) to describe molecular phenotypic "fingerprints" of TI and TII cells, 2) to gain insight into possible functional differences between the two cell types through differentially expressed genes, 3) to identify genes that might indicate potential functions of TI cells, since so little is known about this cell type, and ...[more]

PMID: 15447939

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