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Mapping of H3, H3K4me3, H3K9me3, and H3K9ac on mixed asexual stages of P. falciparum


ABSTRACT: Epigenome profiling has led to the paradigm that promoters of active genes are decorated with H3K4me3 and H3K9ac marks. Data revealed an extensively euchromatic epigenome with heterochromatin restricted to variant surface antigen gene families (VSA) and a number of genes hitherto unlinked to VSA. The vast majority of the genome shows an unexpected pattern of enrichment of H3K4me3 and H3K9ac at intergenic regions and depletion at genes. Chip-chip (and cDNA) from Plasmodium falciparum strain NF54 asexual blood stages with H3, H3K4me3, H3K9me3 and H3K9ac

ORGANISM(S): Plasmodium falciparum

SUBMITTER: O Jensen 

PROVIDER: E-GEOD-15728 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Dynamic histone H3 epigenome marking during the intraerythrocytic cycle of Plasmodium falciparum.

Salcedo-Amaya Adriana M AM   van Driel Marc A MA   Alako Blaise T BT   Trelle Morten B MB   van den Elzen Antonia M G AM   Cohen Adrian M AM   Janssen-Megens Eva M EM   van de Vegte-Bolmer Marga M   Selzer Rebecca R RR   Iniguez A Leonardo AL   Green Roland D RD   Sauerwein Robert W RW   Jensen Ole N ON   Stunnenberg Hendrik G HG  

Proceedings of the National Academy of Sciences of the United States of America 20090602 24


Epigenome profiling has led to the paradigm that promoters of active genes are decorated with H3K4me3 and H3K9ac marks. To explore the epigenome of Plasmodium falciparum asexual stages, we performed MS analysis of histone modifications and found a general preponderance of H3/H4 acetylation and H3K4me3. ChIP-on-chip profiling of H3, H3K4me3, H3K9me3, and H3K9ac from asynchronous parasites revealed an extensively euchromatic epigenome with heterochromatin restricted to variant surface antigen gene  ...[more]

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