Ontology highlight
ABSTRACT:
ORGANISM(S): Plasmodium falciparum
SUBMITTER: O Jensen
PROVIDER: E-GEOD-15728 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Salcedo-Amaya Adriana M AM van Driel Marc A MA Alako Blaise T BT Trelle Morten B MB van den Elzen Antonia M G AM Cohen Adrian M AM Janssen-Megens Eva M EM van de Vegte-Bolmer Marga M Selzer Rebecca R RR Iniguez A Leonardo AL Green Roland D RD Sauerwein Robert W RW Jensen Ole N ON Stunnenberg Hendrik G HG
Proceedings of the National Academy of Sciences of the United States of America 20090602 24
Epigenome profiling has led to the paradigm that promoters of active genes are decorated with H3K4me3 and H3K9ac marks. To explore the epigenome of Plasmodium falciparum asexual stages, we performed MS analysis of histone modifications and found a general preponderance of H3/H4 acetylation and H3K4me3. ChIP-on-chip profiling of H3, H3K4me3, H3K9me3, and H3K9ac from asynchronous parasites revealed an extensively euchromatic epigenome with heterochromatin restricted to variant surface antigen gene ...[more]