Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Affymetrix SNP array data for pediatric acute myeloid leukemia (AML) samples at diagnosis: Sty2 SNP array

ABSTRACT: Genome-wide profiling of Copy Number Alterations (CNA) and Loss of Heterozygosity (LOH), gene expression and resequencing of pediatric AML. This study characterizes the CNA and LOH in a representative cross-section through subtypes of pediatric AML. Affymetrix SNP arrays were performed according to the manufacturer's directions on DNA extracted from cryopreserved diagnostic bone marrow or peripheral blood samples. 111 pediatric AML samples were studied using either Affymetrix 100K + 500K 5.0 SNP arrays, 65 of the samples had paired germ line material. The supplemental files 'GSE15731_AML_175_SNP_Sty_signal.txt' and 'GSE15731_AML_176_SNP_Sty_signal.txt' contain the raw signals generated by dChip without normalization. The CNA and LOH data can be found in the Supplemental Information of the associated manuscript.

ORGANISM(S): Homo sapiens

SUBMITTER: Guangchun Song 

PROVIDER: E-GEOD-15731 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Pediatric de novo acute myeloid leukemia (AML) is an aggressive malignancy with current therapy resulting in cure rates of only 60%. To better understand the cause of the marked heterogeneity in therapeutic response and to identify new prognostic markers and therapeutic targets a comprehensive list of the genetic mutations that underlie the pathogenesis of AML is needed. To approach this goal, we examined diagnostic leukemic samples from a cohort of 111 children with de novo AML using single-nuc  ...[more]

Similar Datasets

Transcriptomics Affymetrix SNP array data for pediatric acute myeloid leukemia (AML) samples at diagnosis: Xba SNP array
2010-01-03 | E-GEOD-15732 | biostudies-arrayexpress
Transcriptomics Affymetrix SNP array data for pediatric acute myeloid leukemia (AML) samples at diagnosis: Hind SNP array
2010-01-03 | E-GEOD-15714 | biostudies-arrayexpress
Transcriptomics Affymetrix SNP array data for pediatric acute myeloid leukemia (AML) samples at diagnosis: Nsp SNP Array
2010-04-13 | E-GEOD-15730 | biostudies-arrayexpress
Genomics Affymetrix SNP array data for pediatric acute myeloid leukemia (AML) samples at diagnosis: Sty2 SNP array
2010-01-04 | GSE15731 | GEO
Genomics Affymetrix SNP array data for pediatric acute myeloid leukemia (AML) samples at diagnosis: Nsp SNP Array
2010-01-04 | GSE15730 | GEO
Genomics Affymetrix SNP array data for pediatric acute myeloid leukemia (AML) samples at diagnosis: Xba SNP array
2010-01-04 | GSE15732 | GEO
Genomics Affymetrix SNP array data for pediatric acute myeloid leukemia (AML) samples at diagnosis: Hind SNP array
2010-01-04 | GSE15714 | GEO
Transcriptomics Upregulation of FOXM1 Induces Genomic Instability in Human Epidermal Keratinocytes
2010-07-29 | E-GEOD-16937 | biostudies-arrayexpress
Transcriptomics Genome-wide LOH and DNA copy number alteration in HPV-neg OSCC and their associations with disease-specific survival
2016-03-23 | E-GEOD-68717 | biostudies-arrayexpress
Transcriptomics GeneChip Mapping 500K set and Genome-Wide Human SNP 6.0 Array in meningioma tumors
2012-11-30 | E-GEOD-42624 | biostudies-arrayexpress