Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Francesca Granucci
PROVIDER: E-GEOD-15759 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Zanoni Ivan I Ostuni Renato R Capuano Giusy G Collini Maddalena M Caccia Michele M Ronchi Antonella Ellena AE Rocchetti Marcella M Mingozzi Francesca F Foti Maria M Chirico Giuseppe G Costa Barbara B Zaza Antonio A Ricciardi-Castagnoli Paola P Granucci Francesca F
Nature 20090614 7252
Toll-like receptors (TLRs) are the best characterized pattern recognition receptors. Individual TLRs recruit diverse combinations of adaptor proteins, triggering signal transduction pathways and leading to the activation of various transcription factors, including nuclear factor kappaB, activation protein 1 and interferon regulatory factors. Interleukin-2 is one of the molecules produced by mouse dendritic cells after stimulation by different pattern recognition receptor agonists. By analogy wit ...[more]