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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse erythroid progenitors (EP) in comparison to granulocyte/monocyte - macrophage progenitors (GMP) from 10 - 16 week old C57/Bl6 - S129Ola

ABSTRACT: Mouse erythroid progenitors (EP) in comparison to granulocyte/monocyte - macrophage progenitors (GMP) from 10 - 16 week old C57/Bl6 - S129Ola (mixed genetic background) purified by flow cytometry

ORGANISM(S): Mus musculus

SUBMITTER: Dirk Carstanjen

PROVIDER: E-GEOD-1584 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Prospective isolation and global gene expression analysis of the erythrocyte colony-forming unit (CFU-E).

Terszowski Grzegorz G Waskow Claudia C Conradt Peter P Lenze Dido D Koenigsmann Jessica J Carstanjen Dirk D Horak Ivan I Rodewald Hans-Reimer HR

Blood 20041102 5

The erythrocyte colony-forming unit (CFU-E) is a rare bone marrow (BM) progenitor that generates erythrocyte colonies in 48 hours. The existence of CFU-Es is based on these colonies, but CFU-Es have not been purified prospectively by phenotype. We have separated the "nonstem," "nonlymphoid" compartment (lineage marker [lin]-c-Kit+Sca-1-IL-7Ralpha-) into interleukin 3 receptor alpha negative (IL-3Ralpha-) and IL-3Ralpha+ subsets. Within IL-3Ralpha- but not IL-3Ralpha+ cells we have identified TER ...[more]

PMID: 15522951

Similar Datasets

EP - GMP

Project description:Mouse erythroid progenitors (EP) in comparison to granulocyte/monocyte - macrophage progenitors (GMP) from 10 - 16 week old C57/Bl6 - S129Ola (mixed genetic background) purified by flow cytometry Keywords = EP Keywords = GMP Keywords = hematopoiesis Keywords: other

2004-10-22 | GSE1584 | GEO

The effect of beta-glucan - induced trained immunity on the transcriptomic profile of bone marrow granulocyte-macrophage progenitors (GMP)

Project description:Induction of trained immunity by beta-glucan affects myeloid cells and their bone marrow progenitors. In particular, broad alterations in the transcriptome of trained myeloid cells have been demonstrated. In this study, we performed RNA sequencing in GMP from beta-glucan treated mice, as compared to control-treated mice, in order to investigate the impact of trained immunity on the transcriptomic profile of GMP.

2020-10-30 | GSE139452 | GEO

Transcription profiling of human HSC enriched population, common myeloid progenitors, granulocyte macrophage progenitors, megakaryocyte progenitors, and leukemia stem cells (leukemic-GMP) reveals MLL-AF9 transforms committed progenitors to leukemia stem cells by activation of a stem cell program (expt 2)

Project description:Leukemias and other cancers possess a rare population of cells capable of self-renewal, and eradication of these cancer stem cells is likely necessary for long-term cancer-free survival. Given that both normal and cancer stem cells are capable of self-renewal the extent to which cancer stem cells resemble normal tissue stem cells is a critical issue if targeted therapies are to be developed. We introduced the MLL-AF9 fusion protein encoded by the t(9;11)(p22;q23) found in human acute myelogenous leukemia (AML) into murine committed granulocyte-macrophage progenitors (GMP). The resultant leukemias contained cells with an immunophenotype similar to normal GMP that were highly enriched for leukemia stem cells (LSC). Detailed gene expression comparisons between normal hematopoietic stem cells (HSC), committed progenitors, and the LSC population demonstrated the LSC were globally more similar to the normal GMP than any other population. However, a subset of genes highly expressed in normal stem cells was re-activated in the LSC. These data demonstrate LSC can be generated from committed progenitors without widespread reprogramming of gene expression, and a leukemia self-renewal associated signature is activated in the process. Our findings define progression from normal hematopoietic progenitor to leukemia stem cell, and suggest that targeting a self-renewal program expressed in an abnormal context may be possible. Experiment Overall Design: A normal HSC enriched population, common myeloid progenitors, granulocyte macrophage progenitors, megakaryocyte progenitors, and leukemia stem cells (leukemic-GMP) were isolated and labeled RNA was hybridzed to Affymetrix microarrays

2008-06-12 | E-GEOD-3722 | biostudies-arrayexpress

The effect of beta-glucan - induced trained immunity on the epigenetic profile of bone marrow granulocyte-macrophage progenitors (GMP) and neutrophils

Project description:Induction of trained immunity by beta-glucan affects myeloid cells and their bone marrow progenitors. In particular, broad epigenetic alterations in trained myeloid cells have been demonstrated. In this study, we performed single cell ATAC sequencing in GMP and neutrophils from beta-glucan treated mice, as compared to control-treated mice, in order to investigate the impact of trained immunity on the epigenetic profile of GMP and neutrophils.

2020-10-30 | GSE152353 | GEO

The effect of beta-glucan - induced trained immunity on the transcriptomic profile of bone marrow granulocyte-macrophage progenitors (GMP) in tumor-bearing mice

Project description:Induction of trained immunity by beta-glucan has been shown to promote transcriptomic alterations in myeloid cells. Progenitors in the bone marrow are also affected by trained immunity and also regulate anti-tumor immune responses . In this study, we performed RNA sequencing in GMP from tumor-bearing mice in order to investigate the impact of trained immunity on the transcriptomic profile of myeloid progenitors in the tumor setting.

2020-10-30 | GSE139456 | GEO

Mus musculus strain:C57/BL6

Project description:Mus musculus strain:C57/BL6

| PRJNA978380 | ENA

GMP-MoPs display mixed gene expression profiles of both neutrophil and monocyte progenitors [RNAseq mouse]

Project description:This analysis was performed to visualize the distinction between GMP-MoPs and other monocyte and neutrophil progenitors. Transcription factors differentially expressed between GMP-MoPs and cMoPs were selected.

2023-03-13 | GSE224102 | GEO

Mus musculus breed:C57/BL6

Project description:Mus musculus breed:C57/BL6 Epigenomics

| PRJNA281127 | ENA

Mus musculus strain:C57/Bl6

Project description:Mus musculus strain:C57/Bl6 Variation

| PRJNA174287 | ENA

Mus musculus strain:C57/BL6

Project description:Mus musculus strain:C57/BL6 Raw sequence reads

| PRJNA281172 | ENA