Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Harikrishna Nakshatri
PROVIDER: E-GEOD-15893 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Appaiah Hitesh H Bhat-Nakshatri Poornima P Mehta Rutika R Thorat Mangesh M Badve Sunil S Nakshatri Harikrishna H
Cancer biology & therapy 20100904 6
CXCR4, a chemokine receptor, plays an important role in breast cancer growth, invasion, and metastasis. The transcriptional targets of CXCR4 signaling are not known. Microarray analysis of CXCR4-enriched and CXCR4-low subpopulations of the MDA-MB-231 breast cancer cell line, which has a constitutively active CXCR4 signaling network, revealed differential expression of ∼ 200 genes in the CXCR4-enriched subpopulation. ITF2, upregulated in CXCR4-enriched cells, was investigated further. Expression ...[more]