Myoblast stimulation with angiotensin II
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Michael Salazar
PROVIDER: E-GEOD-1592 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
E2F-1 regulates the expression of a subset of target genes during skeletal myoblast hypertrophy.
Hlaing Myint M Spitz Paul P Padmanabhan Krishnan K Cabezas Blanca B Barker Christopher S CS Bernstein Harold S HS
The Journal of biological chemistry 20040809 42
Cellular hypertrophy, or growth without division, is an adaptive response to various physiological and pathological stimuli in postmitotic muscle. We demonstrated previously that angiotensin II stimulates hypertrophy in C2C12 myoblasts by transient activation of the cyclin-dependent kinase 4 complex, subsequent phosphorylation of retinoblastoma protein, release of histone deacetylase 1 from the retinoblastoma protein inhibitory complex, and partial activation of the transcription factor E2F-1. T ...[more]
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